CD209 gene polymorphisms in South Indian HIV and HIV-TB patients

Selvaraj, P and Alagarasu, K and Swaminathan, S and Harishankar, M and Narendran, G (2009) CD209 gene polymorphisms in South Indian HIV and HIV-TB patients. Infection, Genetics and Evolution, 9 (2). pp. 256-262. ISSN : 1567-1348; eISSN: 1567-7257

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Abstract

Dendritic-cell-specific intercellular adhesion molecule-3 (ICAM-3)-grabbing non-integrin (DC-SIGN), a pattern recognition receptor, is associated with immune functions and is also exploited by HIV-1 and Mycobacteriumtuberculosis as a part of theirimmune evasion strategy. In the present studyweinvestigated whether variants in the DC-SIGN encoding CD209 gene are associated with susceptibility to or protection against HIV-1 infection as well as development of tuberculosis (TB) among HIV-1 infected south Indian patients. CD209 gene variants in the promoter region (�336 and �139), in the intron and 30-untranslated regions (In2+11 and 2281) were studied using polymerase chain reaction-based genotyping methods in 131 HIV patients without TB (HIV+TB�) and 107 HIV patients with TB (HIV+TB+), 107 HIV negative pulmonary TB patients (HIV�PTB+) and 157 healthy controls. Results revealed a decreased frequency of �336 G/G genotype among all HIV patients compared to healthy controls and �336 G/G genotype was not observed among HIV+TB� individuals (p = 0.005; odds ratio (OR) 0 (95% confidence intervals (CI) 0–0.46); Peto’s odds ratio 0.149 (95% CI 0.045–0.50)). Among HIV+ patients, those with TB had a significantly increased frequency of �336 G/G genotype (p = 0.003; OR undefined; Peto’s odds ratio 9.8 (95% CI 2.2– 44.3)) compared to those without TB. Other polymorphisms were not significantly different between the various study groups. The results suggest that�336 G/G genotype while associated with protection against HIV-1 infection the same genotype is also associated with susceptibility to HIV-TB among south Indians.

Item Type: Article
Uncontrolled Keywords: DC-SIGN CD209 Polymorphisms HIV-1 Tuberculosis HIV-TB
Subjects: Tuberculosis > Laboratory Research > Immunological
HIV
Tuberculosis
Divisions: Basic Science Research > Immunology
Depositing User: Rathinasabapati R
Date Deposited: 04 Aug 2017 10:28
Last Modified: 04 Aug 2017 10:28
URI: http://eprints.nirt.res.in/id/eprint/937

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