Simple and rapid liquid chromatography method for determination of moxifloxacin in plasma

Hemanth Kumar, A K and Ramachandran, Geetha (2009) Simple and rapid liquid chromatography method for determination of moxifloxacin in plasma. Journal of Chromatography B, 877 (11-12). pp. 1205-1208. ISSN 1570-0232

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Abstract

A high performance liquid chromatographic method for determination of moxifloxacin in human plasma was developed. The method involved deproteinisation of the sample with perchloric acid and analysis of the supernatant using a reversed-phase C18 column (150mm) and fluorescence detection at an excitation wavelength of 290nm and an emission wavelength of 460 nm. The assay was specific for moxifloxacin and linear from 0.125 to 10.0�g/ml. The relative standard deviation of intra- and inter-day assays was lower than 10%. The average recovery of moxifloxacin from plasma was 101%. Due to its simplicity, the assay can be used for pharmacokinetic studies of moxifloxacin

Item Type: Article
Uncontrolled Keywords: Moxifloxacin Plasma HPLC
Subjects: Tuberculosis > Laboratory Research > Biochemical,Clinical and Pharmacological
Tuberculosis
Divisions: Basic Science Research > Biochemistry and Pharmacology
Depositing User: Rathinasabapati R
Date Deposited: 10 Aug 2017 07:42
Last Modified: 10 Aug 2017 07:42
URI: http://eprints.nirt.res.in/id/eprint/945

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