Haplotype analysis of HLA-A, -B antigens and -DRB 1 alleles in south Indian HIV-1-infected patients with and without pulmonary tuberculosis

Ragahavan, S and Selvaraj, P and Swaminathan, S and Alagarasu, K and Narendran, G and Narayanan, P R (2009) Haplotype analysis of HLA-A, -B antigens and -DRB 1 alleles in south Indian HIV-1-infected patients with and without pulmonary tuberculosis. International Journal of Immunogenetics, 36 (3). pp. 129-133. ISSN 1744-3121; eISSN: 1744-313X

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Abstract

We have shown earlier the association of human leucocyte antigen (HLA)-A11 with resistance and HLA-B40 and -DR2 with susceptibility to HIV and HIV-TB. In the present study, we have attempted to find out the HLA-DR2 subtypes and the possible HLA-A/-B/-DRB1 haplotype combinations that are associated with susceptibility or resistance to HIV and HIV with pulmonary tuberculosis (HIV + PTB + ). HLA-DR2 subtyping was carried out by polymerase chain reaction-based sequence-specific oligonucleotide probe method. Overrepresentation of HLA-DRB1*1501 in HIV-positive PTB-negative (HIV + PTB–) patients ( P = 0.004, P c = 0.06) and -DRB1*1502 in HIV-positive PTB-positive (HIV + PTB + ) patients ( P = 0.019) was observed as compared to healthy controls. Haplotype analysis revealed an increased frequency of HLA-A2-DRB1*1501 haplotype in HIV + PTB– patients ( P = 0.008) and HLA-A2-DRB1*1502 among HIV + PTB + patients ( P = 0.01) compared to healthy controls. The haplotypes B40-DRB1*1501 and B40-DRB1*04 were found to be moderately increased in HIV + PTB– and HIV + PTB + patients ( P < 0.05). The study suggests that HLA-A2-DRB1*1501 haplotype may be associated with HIV infection while HLAA2- DRB1*1502 haplotype might be associated with susceptibility to PTB in HIV patients. Moreover, HLAB40- DRB1*1501 and HLA-B40-DRB1*04 haplotypes may be associated with susceptibility to HIV infection and to PTB in HIV patients.

Item Type:	Article
Additional Information:	doi: 10.1111/j.1744-313X.2009.00835.x
Uncontrolled Keywords:	Haplotype analysis; HLA-A; DRB1; South India; HIV; pulmonaray tuberculosis
Subjects:	Tuberculosis > Laboratory Research > Immunological Tuberculosis
Divisions:	Basic Science Research > Immunology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	14 Nov 2017 07:09
Last Modified:	02 Mar 2021 06:24
URI:	http://eprints.nirt.res.in/id/eprint/953

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