Attenuation of Toll-Like Receptor Expression and Function in Latent Tuberculosis by Coexistent Filarial Infection with Restoration Following Antifilarial Chemotherapy

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Babu, Subash and Bhat, S Q and Pavan Kumar, N and Anuradha, R and Paul Kumaran, P and Gopi, P G and Kolappan, C and Kumaraswami, V and Nutman, T B (2009) Attenuation of Toll-Like Receptor Expression and Function in Latent Tuberculosis by Coexistent Filarial Infection with Restoration Following Antifilarial Chemotherapy. PLOS Neglected Tropical Diseases, 3 (7). pp. 1-8. ISSN : 1935-2727; eISSN: 1935-2735

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Abstract

Mycobacterium tuberculosis (Mtb) and filarial coinfection is highly prevalent, and the presence of filarial infections may regulate the Toll-like receptor (TLR)-dependent immune response needed to control Mtb infection. By analyzing the baseline and mycobacterial antigen–stimulated expression of TLR1, 2, 4, and 9 (in individuals with latent tuberculosis [TB] with or without filarial infection), we were able to demonstrate that filarial infection, coincident with Mtb, significantly diminishes both baseline and Mtb antigen-specific TLR2 and TLR9 expression. In addition, pro-inflammatory cytokine responses to TLR2 and 9 ligands are significantly diminished in filaria/TB-coinfected individuals. Definitive treatment of lymphatic filariasis significantly restores the pro-inflammatory cytokine responses in individuals with latent TB. Coincident filarial infection exerted a profound inhibitory effect on protective mycobacteria-specific TLR-mediated immune responses in latent tuberculosis and suggests a novel mechanism by which concomitant filarial infections predispose to the development of active tuberculosis in humans.

Item Type: Article
Uncontrolled Keywords: Latent Tuberculosis; Filarial
Subjects: Tuberculosis > Laboratory Research > Immunological
Filariasis
Tuberculosis
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 14 Nov 2017 10:09
Last Modified: 02 Mar 2021 05:11
URI: http://eprints.nirt.res.in/id/eprint/959

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