Characterization of HIV-1 Isolates from Antiretroviral Drug-Naive Children in Southern India

Soundararajan, L and Karunaianandham, R and Jauvin, V and Schrive, M H and Ramachandran, Ranjani and Narayanan, P R and Fleury, H J and Swaminathan, Soumya (2007) Characterization of HIV-1 Isolates from Antiretroviral Drug-Naive Children in Southern India. AIDS Research and Human Retroviruses, 23 (9). pp. 1119-1126. ISSN Print: 0889-2229; Online: 1931-8405

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Abstract

Access to antiretroviral therapy has expanded in many developing countries, including India. The standard first-line regimens consist of a combination of two nucleoside reverse transcriptase inhibitors and a nonnucleoside reverse transcriptase inhibitor, in a fixed drug combination. Data regarding resistance to these drugs are scarce, especially in children. We evaluated the pattern of polymorphism and potential drug resistance mutations (DRMs) in HIV-1 isolates from 48 children naive to antiretroviral therapy attending the outpatient clinics of the Tuberculosis Research Center in Chennai. The samples were subjected to genotyping of reverse transcriptase (RT) and protease genes. All the samples showed significant polymorphisms in both RT and protease genes, but none had major DRMs. The currently recommended generic first-line antiretroviral drug combination is an appropriate treatment strategy for HIV-1-infected children in India.

Item Type: Article
Subjects: Tuberculosis > Laboratory Research > Bacteriological
Divisions: Basic Science Research > Bacteriology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 08 Jan 2014 09:54
Last Modified: 30 Mar 2021 05:29
URI: http://eprints.nirt.res.in/id/eprint/809

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