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Regulatory T Cells Modulate Thl7 Responses in Patients with Positive Tuberculin Skin Test Results

Bhat, Sajid Q and Pavan Kumar, N and Nutman, Thomas B (2010) Regulatory T Cells Modulate Thl7 Responses in Patients with Positive Tuberculin Skin Test Results. Journal of Infectious Diseases, 201 (1). pp. 20-31. ISSN ISSN: 0022-1899; ESSN: 1537-6613

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Background. The factors governing latency in tuberculosis are not well understood but appear to involve both the pathogen and the host. We have used tuberculin skin test (TST) positivity as a tool to study cytokine responses in latent tuberculosis. Methods. To identify the host factors that are important in the maintenance of TST positivity, we examined mycobacteria-specific immune responses of TST-positive (latent tuberculosis) or TST-negative individuals in South India, where TST positivity can define tuberculosis latency. Results. Although purified protein derivative-specific and Mycobacterium tuberculosis culture filtrate antigen specific Thl and Th2 cytokines were not statistically significantly different between the 2 groups, the Thl7 cytokines (interleukin 17 and interleukin 23) were statistically significantly decreased in TST-positive individuals, compared with those in TST-negative individuals. This Thl7 cytokine modulation was associated with statistically significantly increased expression of cytotoxic T lymphocyte antigen 4 (CTLA-4) and Foxp3. Although CTLA-4 blockade failed to restore full production of interleukin 17 and interleukin 23 in TST-positive individuals, depletion of regulatory T cells significantly increased production of these cytokines. Conclusion. TST positivity is characterized y increased activity of regulatory T cells and a coincident down regulation of the Thl7 response.

Affiliation: National Institute for Research in Tuberculosis
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Item Type: Article
Additional Information: RP201001
Uncontrolled Keywords: T Cells; Thl7; Tuberculin; Skin Test
Subjects: Tuberculosis > Laboratory Research
Tuberculosis > Laboratory Research > Immunological
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 29 Apr 2020 14:00
Last Modified: 29 Apr 2020 14:00

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