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Regulatory T Cells Modulate Thl7 Responses in Patients with Positive Tuberculin Skin Test Results

Bhat, Sajid Q and Pavan Kumar, N and Nutman, Thomas B (2010) Regulatory T Cells Modulate Thl7 Responses in Patients with Positive Tuberculin Skin Test Results. Journal of Infectious Diseases, 201 (1). pp. 20-31. ISSN ISSN: 0022-1899; ESSN: 1537-6613

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Abstract

Background. The factors governing latency in tuberculosis are not well understood but appear to involve both the pathogen and the host. We have used tuberculin skin test (TST) positivity as a tool to study cytokine responses in latent tuberculosis. Methods. To identify the host factors that are important in the maintenance of TST positivity, we examined mycobacteria-specific immune responses of TST-positive (latent tuberculosis) or TST-negative individuals in South India, where TST positivity can define tuberculosis latency. Results. Although purified protein derivative-specific and Mycobacterium tuberculosis culture filtrate antigen specific Thl and Th2 cytokines were not statistically significantly different between the 2 groups, the Thl7 cytokines (interleukin 17 and interleukin 23) were statistically significantly decreased in TST-positive individuals, compared with those in TST-negative individuals. This Thl7 cytokine modulation was associated with statistically significantly increased expression of cytotoxic T lymphocyte antigen 4 (CTLA-4) and Foxp3. Although CTLA-4 blockade failed to restore full production of interleukin 17 and interleukin 23 in TST-positive individuals, depletion of regulatory T cells significantly increased production of these cytokines. Conclusion. TST positivity is characterized y increased activity of regulatory T cells and a coincident down regulation of the Thl7 response.

Affiliation: National Institute for Research in Tuberculosis
NIRT Creators:
NIRT CreatorsEmail
Babu, SubashUNSPECIFIED
Kumaraswami, VUNSPECIFIED
Item Type: Article
Additional Information: RP201001
Uncontrolled Keywords: T Cells; Thl7; Tuberculin; Skin Test
Subjects: Tuberculosis > Laboratory Research
Tuberculosis > Laboratory Research > Immunological
Tuberculosis
Divisions: Basic Science Research > Immunology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 29 Apr 2020 14:00
Last Modified: 29 Apr 2020 14:00
URI: http://eprints.nirt.res.in/id/eprint/1013

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