Specific Allergic sensitisation to filarial antigens in tropical eosinophilia syndrome

Ottesen, E A and Neva, F A and Paranjape, R S and Tripathy, S P and Thiruvengadam, K V and Beaven, M A (1979) Specific Allergic sensitisation to filarial antigens in tropical eosinophilia syndrome. Lancet, 313 (8127). pp. 1158-1161. ISSN 0140-6736

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Reaginic antibodies to antigens from the human filarial parasites Wuchereria bancrofti and Brugia malayi and the animal parasite Dirofilaria immitis were studied by histamine release from basophils in 7 patients with tropical eosinophilia (T.E.) and 18 patients with other manifestations of filarial infection (lymphatic changes or symptomless microfilaræmia). All the patients had antibodies to all three filariæ but T.E. patients were more highly sensitised., T.E. patients responded more to antigens from microfilariæ than did patients with non-T.E. filariasis and responded more to microfilarial antigens from the human parasites than to those from the animal parasite. These findings support the view that T.E. is a form of occult filariasis which results from host hypersensitivity to the microfilarial stage of parasites which, in other individuals, cause the more common lymphatic manifestations of filarial disease.

Item Type: Article
Subjects: Tuberculosis > Laboratory Research
Tuberculosis > Clinical Research
Divisions: Basic Science Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 25 Jul 2013 10:38
Last Modified: 11 Mar 2016 04:53
URI: http://eprints.nirt.res.in/id/eprint/138

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