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The Results of Treatment with Streptomycin Plus Pyrazinamide in Patients with Active Pulmonary Tuberculosis Despite Prolonged Treatment with Isoniazid Plus PAS

Velu, S and Andrews, R H and Devadatta, S and Fox, Wallace (1960) The Results of Treatment with Streptomycin Plus Pyrazinamide in Patients with Active Pulmonary Tuberculosis Despite Prolonged Treatment with Isoniazid Plus PAS. Indian Journal of Tuberculosis, 7 (3). pp. 85-94. ISSN 0019-5705

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Abstract

This report presents the findings during a year or more of observation of 20 South Indian patients who, after an initial course of isoniazid plus PAS, were treated with streptomycin plus pyrazinamide for active pulmonary tuberculosis. The combination of streptomycin plus pyrazinamide was chosen, first, because of its likely therapeutic effectiveness, since all the patients had streptomycin-sensitive strains of bacilli, secondly, because it presented an opportunity to study supervised drug administration in domiciliary patients in a community in which the selfadministration of antituberculosis drugs could not be depended on (Fox, 1958 ; Tuberculosis Chemotherapy Centre, 1959, 1960 ; Velu et al., 1960). The patients were either unsuitable for or unwilling to undergo surgery.

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Item Type: Article
Subjects: Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 12 Jul 2013 11:12
Last Modified: 08 Mar 2016 04:26
URI: http://eprints.nirt.res.in/id/eprint/22

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