Correlation of lower respiratory tract inflammation with changes in lung function and chest roentgenograms in patients with untreated tropical pulmonary eosinophilia

Vijayan, V K and Sankaran, K and Venkatesan, P and Kuppurao, K V (1991) Correlation of lower respiratory tract inflammation with changes in lung function and chest roentgenograms in patients with untreated tropical pulmonary eosinophilia. Singapore Medical Journal, 32 (3). pp. 122-125. ISSN 0037-5675

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Official URL: http://smj.sma.org.sg/3203/3203a1.pdf

Abstract

Forty-one patients with untreated tropical pulmonary eosinophilia (TPE) were studied to determine whether there was any relationship between lower respiratory tract inflammation and either changes in lung function or abnormalities in chest roentgenograms. Total number of inflammatory cells in bronchoalveolar lavage (BAL)fluid, consisting of alveolar macrophages, lymphocytes, eosinophils and neutrophils had significant negative correlations with transfer factor (TLCO) (r=-0519, p<0.001), transfer coefficient (KCO) (r=-0.3!2, p<0.05) and total lung capacity (TLC) (r=-0.352, p<0.05). The absolute count of eosinophils in BAL fluid had a signifiant negative correlation with TLC0 (r=-0.430, p<0.01) and KC0 (r=-0.300, p=0.05), but not with forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) or TLC. However, the absolute count of alveolar macrophages had a significant negative correlation with FVC (r=-0.343, p<0.05), FEVI (r=-0.341, p<0.05) and TLC (r=-0.305, p<0.05), but not with TLC0 or KCO. The total number of lymphocytes had a negative correlation with TLC (r=-0.315, p<0.05). There was no correlation between the types of cells recovered in BAL/fluid and changes in chest radiographs as assessed by the IL0 classification for occupational lung diseases. These data suggest that there may be a dissociation of pulmonary pathophysiological changesproduced by different inflammatory cells in the lower respiratory tract. Macrophages and lymphocytes may produce more harm to the lung, as evidenced by significant negative correlations of these cells with lung volumes.

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