Balasubramanian, R and Ramachandran, R
(2000)
Management of Non-Pulmonary Forms of Tuberculosis : Review of TRC
Studies over Two Decades.
Indian Journal of Pediatrics, 67.
S34-S40.
ISSN Print: 0019-5456; Online: 0973-7693
Abstract
Tuberculosis Research Centre, Chennai has been conducting randomized controlled clinical trials in both
adults and children (n = 1015) in various non-pulmonary forms of tuberculosis, for the last two decades. This
communication discusses the salient findings of these studies. The important finding is that short course
chemotherapeutic regimens have been proven to be highly effective in tuberculosis of spine, superficial tuberculous
lymphadenitis, abdominal tuberculosis, brain tuberculoma and Potts paraplegia. However, in tuberculous meningitis,
the outcome appears to be directly related to the stage of the disease on admission. The intermittent regimens have
been found to be as effective as daily regimens. The other important aspects highlighted are the need to obtain
bacteriological/histo-pathological confirmation by resorting to relevant diagnostic procedures, value of Mantoux as a
diagnostic tool and role of surgery.
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