Selvaraj, P and Chandra, G and Kurian, S M and Reetha, A M and Charles, N and Narayanan, P R
(2002)
NRAMP1 gene polymorphism in
pulmonary and spinal tuberculosis.
Current Science, 82 (4).
pp. 451-454.
ISSN 0011-3891
Abstract
NRAMP1 gene polymorphisms such as 823 C/T (exon
8), deletion of TGTG in the 3'-UTR (3¢ untranslated
region) and D543N G/A (exon 15) were studied to
find out whether the gene polymorphic variants are
associated with the susceptibility or resistance to
tuberculosis (TB). The study was carried out in pulmonary
(n = 100) and spinal TB patients (n = 57) and
control subjects (n = 112). No difference was observed
in the variant genotype frequencies of
NRAMP1 – 823 C/T, TGTG+/del and D543N G/A
polymorphisms. However, a trend towards an increased
frequency of the variant genotype 823 C/T
(heterozygotes) was observed in pulmonary TB patients
than control and spinal TB patients (odds ratio
(OR) : 1.6; confidence interval (CI): 0.74–3.4). A
trend towards an increased frequency of the variant
genotype TGTG del/del of 3'-UTR was observed in
control subjects than pulmonary and spinal TB patients
(OR : 0.48; CI: 0.10–1.78; OR: 0.42; CI: 0.04–
2.12, respectively). The above trends were not significant.
The study suggests that NRAMP1 gene may
not be associated with the susceptibility to pulmonary
and spinal TB in the Indian population. Major
Histocompatibility Complex (MHC) and other non-
MHC gene polymorphic variants may be associated.
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