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Defective Solubilization of Immune Complexes and Activation of the Complement System in Patients with Pulmonary Tuberculosis

Senbagavalli, P and Geetha, S T and Venkatesan, P and Ramanathan, V D (2009) Defective Solubilization of Immune Complexes and Activation of the Complement System in Patients with Pulmonary Tuberculosis. Journal of Clinical Immunology, 29 (5). pp. 674-680. ISSN Print: 0271-9142; Online: 1573-2592

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Official URL: https://link.springer.com/article/10.1007/s10875-0...

Abstract

Introduction Association between inherited deficiencies of the complement components and immune complex disease indicates the importance of the complement system in the handling of circulating immune complexes. High levels of circulating immune complexes are seen in pulmonary tuberculosis. This study is, therefore, aimed to look at the concentration of circulating immune complexes, the status of complement-mediated immune complex handling, and the extent of complement activation in untreated pulmonary tuberculosis compared to treated pulmonary tuberculosis patients and healthy controls. Results High immune complex levels, decreased complementmediated solubilization, and increased activation of the complement system were observed in untreated tuberculosis patients. Conclusions The results obtained from the present study suggest that complement mediated solubilization is less in patients with tuberculosis, and this defective solubilization is likely to take part in a vicious cycle involving immune complex deposition and complement activation and, thus, may lead to disease progression depending on the nature of the defect.

NIRT Creators:
NIRT CreatorsEmail
Item Type: Article
Uncontrolled Keywords: Circulating immune complexes' pulmonary tuberculosis; the complement system; solubilization of immune complexes; complement activation fragments; prevention of immune complex precipitation
Subjects: Tuberculosis > Laboratory Research > Biochemical,Clinical and Pharmacological
Tuberculosis
Divisions: Basic Science Research > Biochemistry and Pharmacology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 16 Nov 2017 11:38
Last Modified: 16 Nov 2017 11:38
URI: http://eprints.nirt.res.in/id/eprint/968

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