A qualitative test for the determination of isoniazid acetylator phenotype

Raghupati Sarma, G and Kannapiran, M and Narayana, A S L and Radhakrishna, S (1978) A qualitative test for the determination of isoniazid acetylator phenotype. Indian Journal of Medical Research, 68 (8). pp. 335-340. ISSN 0971-5916

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Abstract

A qualitative test procedure for phenotyping isoniazid acetylators is described. It is based on a colour reaction which depends on the free sulphadimidine content in the total urine excreted over any one-hour period between 21 and 26 hours following a dose of sulphadimidine 1.0 or 1.5 g. depending on body-weight. The test correctly classified 96 per cent of 109 slow and 96 per cent of 68 rapid inactivators. Storage of urine samples at room-temperature up to 14 days did not affect the accuracy of the results.

Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/133

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