Downregulation of monocyte miRNAs: implications for immune dysfunction and disease severity in drug-resistant tuberculosis

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Sampath, Pavithra and Moorthy, Manju and Menon, Athul and Madhav, Lekshmi and Janaki, Aishwarya and Dhanapal, Madhavan and Palaniappan, Alangudi Natarajan and Hissar, Syed and Ranganathan, Uma Devi and Ramaswamy, Gopalakrishna and Bethunaickan, Ramalingam (2023) Downregulation of monocyte miRNAs: implications for immune dysfunction and disease severity in drug-resistant tuberculosis. Frontiers in Immunology, 14 (119780). 01-16. ISSN 1664-3224

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Official URL: https://www.frontiersin.org/journals/immunology

Abstract

Monocyte miRNAs govern both protective and pathological responses during tuberculosis (TB) through their differential expression and emerged as potent targets for biomarker discovery and host-directed therapeutics. Thus, this study examined the miRNA profile of sorted monocytes across the TB disease spectrum [drug-resistant TB (DR-TB), drug-sensitive TB (DS-TB), and latent TB] and in healthy individuals (HC) to understand the underlying pathophysiology and their regulatory mechanism.

Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/1970

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