Downregulation of monocyte miRNAs: implications for immune dysfunction and disease severity in drug-resistant tuberculosis

Sampath, Pavithra and Moorthy, Manju and Menon, Athul and Madhav, Lekshmi and Janaki, Aishwarya and Dhanapal, Madhavan and Palaniappan, Alangudi Natarajan and Hissar, Syed and Ranganathan, Uma Devi and Ramaswamy, Gopalakrishna and Bethunaickan, Ramalingam (2023) Downregulation of monocyte miRNAs: implications for immune dysfunction and disease severity in drug-resistant tuberculosis. Frontiers in Immunology, 14 (119780). 01-16. ISSN 1664-3224

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Abstract

Monocyte miRNAs govern both protective and pathological responses during tuberculosis (TB) through their differential expression and emerged as potent targets for biomarker discovery and host-directed therapeutics. Thus, this study examined the miRNA profile of sorted monocytes across the TB disease spectrum [drug-resistant TB (DR-TB), drug-sensitive TB (DS-TB), and latent TB] and in healthy individuals (HC) to understand the underlying pathophysiology and their regulatory mechanism.

Item Type:	Article
Uncontrolled Keywords:	Downregulation monocyte miRNAs immune dysfunction disease severity drug-resistant tuberculosis
Subjects:	Tuberculosis > Laboratory Research Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Immunology
Depositing User:	Mrs. N Lakshmi
Date Deposited:	24 Jul 2023 10:13
Last Modified:	24 Jul 2023 10:53
URI:	http://eprints.nirt.res.in/id/eprint/1970

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