First- and second-line drug resistance patterns among previously treated tuberculosis patients in India

Paramasivan, C N and Rehman, F and Wares, F and Sundar Mohan, N and Sundar, S and Devi, S and Narayanan, P R (2010) First- and second-line drug resistance patterns among previously treated tuberculosis patients in India. International Journal of Tuberculosis and Lung Disease, 14 (2). pp. 243-246. ISSN Print: 1027-3719 | Electronic: 1815-7920

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Abstract

Culture and drug susceptibility testing results of 2816 tuberculosis (TB) patients from across India who had failed repeated treatments from 2001 to 2004 were retrospectively analysed at the Tuberculosis Research Centre, Chennai. Of 1498 (53%) identifi ed as having multidrugresistant TB (MDR-TB), 671 (44.8%) were resistant to ⩾1 second-line drugs (SLDs): 490 (32.7%) to ethionamide, 245 (16.4%) to ofl oxacin and 169 (11.3%) to kanamycin; 69 (4.6%) were extensively drug-resistant TB (XDR-TB). Although from a highly select and nonrepresentative patient group, such high SLD resistance levels, including XDR-TB, among MDR-TB patients is of concern. The prevention of MDR/XDR-TB through quality DOTS services, however, remains the priority. In addition, rapid scale-up of quality programmatic management under the RNTCP is needed, with more control and rational use of SLDs outside the programme. KEY WORDS: drug resistance; previously treated tuberculosis; India

Affiliation:	National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	drug resistance; previously treated tuberculosis; India
Subjects:	Tuberculosis > Laboratory Research > Bacteriological
Divisions:	Basic Science Research > Bacteriology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	17 Mar 2022 07:35
Last Modified:	17 Mar 2022 07:35
URI:	http://eprints.nirt.res.in/id/eprint/1024

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