Yield of QuantiFERON-TB gold in tube assay and tuberculin skin test in healthy persons from a tuberculosis endemic population

Basirudeen, S A K and Venkatesan, P and Paulkumaran, P and Alamelu, Raja (2010) Yield of QuantiFERON-TB gold in tube assay and tuberculin skin test in healthy persons from a tuberculosis endemic population. Journal of Pediatric Diseases, 5. pp. 125-129. ISSN 1305-7707

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Abstract

Abstract. We assessed the yield of the QuantiFERON-TB Gold in tube test (QFT-GIT) and the tuberculin skin test (TST) in healthy persons from our general population, where tuberculosis is endemic and Bacillus Calmette-Gu´erin is mandatory. The yield of QFT-GIT (2%) and TST (1%) were very low among children, where the test was positive in 42% and 24% of adults, respectively. Our study results show that QFT-GIT and TST are not influenced by prior Bacillus Calmette-Gu´erin vaccination. Applying the reduced cut-off point of 0.13 IU/mL is adequate in a pediatric population. Moreover, both the TST and the QFT-GIT demonstrated a low yield in the pediatric population, which suggests that either TST or QFT-GIT alone or in combination can be used to diagnose Mycobacterium tuberculosis infection in our setting.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	Tuberculosis, diagnosis, QuantiFERON-TB Gold in tube, healthy children, endemic population
Subjects:	Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Immunology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	13 May 2022 09:52
Last Modified:	25 May 2022 10:45
URI:	http://eprints.nirt.res.in/id/eprint/1048

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