Sulphadimidine Acetylation Test for Classification of Patients as Slow or Rapid Inactivators of Isoniazid

Rao, K V N and Mitchison, D A and Nair, N G K and Prema, K and Tripathy, S P (1970) Sulphadimidine Acetylation Test for Classification of Patients as Slow or Rapid Inactivators of Isoniazid. British Medical Journal, 3 (5721). pp. 495-497. ISSN 1756-1833

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Abstract

Summary: Sulphadimidine acetylation studies were undertaken in 103 patients, 52 of whom had been classified as slow and 51 as rapid inactivators of isoniazid by a standard microbiological assay method. Each patient received sulphadimidine by mouth in a dose of 44 mg./kg. body weight, and free and total sulphadimidine were estimated in blood and urine collected at six hours. The findings suggest that patients may be classified as slow inactivators of isoniazid if the proportion of acetylated sulphadimidine (total minus free) is (a) less than 25% in blood or (b) less than 70% in urine. The sulphadimidine test is easy to perform and the result is available the same day; urine specimens for the test can be stored at room temperature for over a week without any loss of drug.

Item Type:	Article
Subjects:	Tuberculosis > Clinical Research
Divisions:	Clinical Research
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	19 Jul 2013 10:49
Last Modified:	08 Mar 2016 08:58
URI:	http://eprints.nirt.res.in/id/eprint/108

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