Drug resistanceamongdifferentgenotypesof Mycobacteriumtuberculosis isolated from patientsfromTiruvallur,SouthIndia

Shanmugam, Sivakumar and Selvakumar, N and Narayanan, Sujatha (2011) Drug resistanceamongdifferentgenotypesof Mycobacteriumtuberculosis isolated from patientsfromTiruvallur,SouthIndia. Infection, Genetics and Evolution, 11 (5). pp. 980-986. ISSN Online 1567-1348

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Abstract

India continuestohavethehighesttuberculosisincidence,accountingforonefifthoftheglobal incidenceand2/3rdofthecasesinsouthEastAsia.TheTBburdenisalsoaugmentedbymultidrug resistanceandHIV.Althoughinadequateandinappropriatetreatmentisresponsiblefordrugresistance, pathogen’sgeneticbackgroundmayalsoplayarole.Theaimofthisstudywastounderstandthe distributionofdifferentgenotypesof Mycobacteriumtuberculosis in theTiruvallur,ruralareainSouth India anditsassociationwithdrugresistance.Atotalof1649 M. tuberculosis isolatesweregenotypedby IS6110RFLPandspoligotyping.Drugsusceptibilitytestingwasdonebyminimuminhibitory concentrationmethod(MIC)onallthesamples.Asreportedearlier,theisolateswithsingleandlow copy IS6110accountedfor66%amongthe1649 M. tuberculosis strains genotyped.Themajority(84%)of our strainsbelongedtotheEastAfricanIndian(EAI)lineage,28.6%toEAI3sublineageand19.5%toEAI5 sublineage.RifampicinandstreptomycinmonoresistancefollowedbyMDR(Multi-DrugResistance, resistancetoatleastrifampicinandisoniazid)[(OR0.2[95%CI0.11-0.46],P < 0.05)] weremorecommon betweenCentralAsian(CAS),TandBeijingcomparedtoEAIlineage.InspiteofthepredominanceofEAI lineage,itsassociationwithdrugresistancewaslowercomparedtotheothergenotypesprevalentin Tiruvallur,SouthIndia

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/1099

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