Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis

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Unissa, A N and Sudha, Subramanian and Selvakumar, N and Hassan, Sameer (2011) Binding of activated isoniazid with acetyl-CoA carboxylase from Mycobacterium tuberculosis. Bioinformation, 7 (3). pp. 107-111. ISSN Print 0973-8894 | Online 0973-2063

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Official URL: https://bioinformation.net/007/97320630007107.pdf

Abstract

AccD6 (acetyl coenzyme A (CoA) carboxylase), plays an important role in mycolic acid synthesis of Mycobacterium tuberculosis (Mtb). Induced gene expression by isoniazid (isonicotinylhydrazine - INH), anti-tuberculosis drug) shows the expression of accD6. It is our interest to study the binding of activated INH with the AccD6 model using molecular docking procedures. The study predicts a primary binding site for activated INH (isonicotinyl acyl radical) in AccD6 as a potential target.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/1110

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