Rathinam, P. and Devi, PoornaGanga (2017) Xpert MTB/RIF assay for the diagnosis of pulmonary and extra pulmonary tuberculosis. IOSR-Journal of Dental and Medical Sciences, 16 (8). pp. 86-88. ISSN Online: 2279-0853 | Print 2279-086
![[thumbnail of 201756.pdf]](http://eprints.nirt.res.in/style/images/fileicons/archive.png) |
Archive
201756.pdf - Published Version Download (227kB) |
Abstract
Detecting patients with active Tuberculosis (TB) disease is an important component of tuberculosis control programs, as early diagnosis and treatment of tuberculosis is essential in reducing the morbidity, mortality and the escalating costs associated with advanced disease. We conducted this study to access the usefulness of Gene Xpert MTB/RIF assay technique in the diagnosis of tuberculosis and rifampicin (Rif) resistance. We retrospectively reviewed the clinical records and rapid diagnostic results of all patients with suspected Tuberculosis who visited the pulmonary clinic of Government Rajaji Hospital (GRH), Madurai from January 2017 to June 2017. Various pulmonary and extra pulmonary specimens were collected under aseptic precautions. These Xpert MTB/RIF samples were processed according to the manufacturer’s specifications. A total of 764 consecutive pulmonary and extra pulmonary clinical samples were included. Out of 764 samples, 136 (18%) tested positive for M.tuberculosis. Of these 136 positive samples, 124 (91.2%) were found to be Rif sensitive and 10 (7.4%) were found to be Rif resistant. Rif resistant cases were referred for initiation of MDR treatment. This study shows that GenXpert is useful in the early diagnosis of Rif resistance in both pulmonary and extrapulmonary specimens.
| Affiliation: | ICMR-National Institute for Research in Tuberculosis |
|---|---|
| Item Type: | Article |
| Uncontrolled Keywords: | Gene-Xpert, tuberculosis, pulmonary, extrapulmonary |
| Subjects: | Tuberculosis > Clinical Research |
| Divisions: | Clinical Research |
| Depositing User: | Dr. Rathinasabapati R |
| Date Deposited: | 20 Oct 2022 10:33 |
| Last Modified: | 20 Oct 2022 10:33 |
| URI: | http://eprints.nirt.res.in/id/eprint/1546 |
Actions (login required)
 |
View Item |