Uric acid disposition during intermittent chemotherapy of pulmonary tuberculosis with regimens containing pyrazinamide & rifampicin

Kannapiran, M and Krishnamurthy, P V and Raghupati Sarma, G (1985) Uric acid disposition during intermittent chemotherapy of pulmonary tuberculosis with regimens containing pyrazinamide & rifampicin. Indian Journal of Medical Research, 82 (2). pp. 116-121. ISSN 0971-5916

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Abstract

Uric acid disposition during intermittent chemotherapy of pulmonary tuberculosis was studied in 13 patients allocated to a thrice-weekly regimen containing pyrazinamide in addition to rifampicin, isoniazid and streptomycin and in 19 patients allocated to a twice-weekly regimen of the same four drugs; the dosage of pyrazinam ide was 50 mg/kg in the former and 70 mg/kg in the latter. In the thrice-weekly series, the mean serum uric acid concentration ½ h before drug administration at 2 months (5.5 mg/dl) was significantly higher (P< 0.001) than that on admission (3.2 mg/ dl); hyperuricaemia (>7 mg/dl) was observed in none of the patients on admission and in 3 at 2 months. In the twice-weekly series, the two values (3.4 and 3.1 mg/dl, respectively) were similar, and none of the patients bad hyperuricaemia. The mean concentrations 5 h after drug administration at 2 months were significantly higher (P< 0.001) than those before drug administration in both the series (6.6 and 4.8 mg/dl, respectively), and hyperuricaemia was observed in 4 patients, all in the thrice weekly series.

Item Type:	Article
Subjects:	Tuberculosis > Laboratory Research > Biochemical
Divisions:	Basic Science Research > Biochemistry
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	08 Aug 2013 11:22
Last Modified:	17 Mar 2016 08:57
URI:	http://eprints.nirt.res.in/id/eprint/186

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