Pulmonary and response to treatment in an outpatient setting: Case series.

Gopalaswamy, Radha and Padmapriyadarsini, Chandrasekaran and Sekar, Krithikaa and Vijayaragavan, Vaishnavee and Bhavani, Perumal Kannabiran and Lokanathan, Lakshana Malla and Anandakrishnan, Sundararajaperumal and Sivaramakrishnan, Gomathi (2021) Pulmonary and response to treatment in an outpatient setting: Case series. International journal of mycobacteriology, 10 (1). pp. 93-97. ISSN 2212-554X

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Abstract

Pulmonary disease due to Mycobacterium abscessus (Mab) has become an increasing cause of health concern, particularly among individuals infected with nontuberculous mycobacteria. Since Mab is intrinsically resistant to many antibiotics, it is very challenging to treat patients with symptomatic disease. In this case series, we report four patients with symptomatic pulmonary Mab who had prior history of antituberculosis treatment intake and declared cured at the end of treatment. The current episode was confirmed to be due to Mab infection by molecular and clinical diagnosis and received species specific-antibiotics therapy. All were periodically monitored for the sputum smear and culture conversions throughout the treatment period. The clinical course was variable though all received similar antibiotic regimen and showed varied treatment outcomes. The time of diagnosis and the treatment outcome indicate that a better understanding of host-pathogen interactions is essential for the successful treatment of pulmonary Mab infection.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	Antibiotics; Mycobacterium abscessus; line probe assay; oral macrolide; pulmonary disease.
Subjects:	Tuberculosis > Laboratory Research > Bacteriological
Divisions:	Basic Science Research > Bacteriology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	29 Nov 2022 11:06
Last Modified:	29 Nov 2022 11:06
URI:	http://eprints.nirt.res.in/id/eprint/1867

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