Dodecanoic acid & palmitic acid disarms rifampicin resistance by putatively targeting mycobacterial efflux pump Rv1218c

Nirmal, CR and Rajadas, SE and Balasubramanian, M and Magdaline, D and Chilamakuru, NB and Dinesh, R and Radhakrishnan, A and Paraman, R and Mondal, R and Dusthackeer, AVN (2023) Dodecanoic acid & palmitic acid disarms rifampicin resistance by putatively targeting mycobacterial efflux pump Rv1218c. Scientifc Reports, 157 (2&3). pp. 197-203.

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Abstract

Background & objectives: Drug-resistant tuberculosis (TB) jeopardizes the treatment process with poor outcomes. Efflux pumps (EPs) belonging to the ABC transporter family in Mycobacterium tuberculosis confer resistance to rifampicin (RMP) besides genetic mutations thus serving as a target for a potential adjunct therapeutic inhibitory molecule. Rv1218c is one such pump that was previously reported to be active in multidrug-resistant TB clinical isolates.

Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/1963

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