Prevalence and factors associated with tuberculosis infection in India

Selvaraju, Sriram and Velayutham, Banurekha and Rao, Raghuram and Rade, Kiran and Thiruvengadam, Kannan and Asthana, Smita and Balachandar, Rakesh and Bangar, SampadaDipak and Bansal, Avi Kumar and Bhat, Jyothi and Chopra, Vishal and Das, Dasarathi and Dutta, Shanta and Devi, Kangjam Rekha and Dwivedi, Gaurav Raj and Kalliath, Atshad and Laxmaiah, Avula and Madhukar, Manoj and Mahapatra, Amarendra and Mohanty, Suman Sundar and Rangaraju, Chethana and Turuk, Jyotirmayee and Menon, Pradeep A. and Krishnan, Rajendran and Singh, Manjula and Sekar, Krithikaa and Robinson, Aby and Turuk, Alka and Krishnan, Nivethitha N. and Srinivasan, Nivetha and Rexy, Catherine and Suresh, M and Hanna, Luke Elizabeth and Choudhury, Avijit H and Parmar, Malik and Ramachandran, Ranjani and Kumar, Nishant and Joshi, Rajendra Panduranga and Narasimhaiah, Somashekar and Chandrasekaran, Padmapriyadarsini and Khan, A. M. and Panda, Samiran and Bhargava, Balram (2023) Prevalence and factors associated with tuberculosis infection in India. Prevalence and factors associated with tuberculosis infection in India, 16 (1876). pp. 1-8.

Text TB Infection in India.pdf - Published Version Download (4MB)

Abstract

Background: The risk of tuberculosis (TB) disease is higher in individuals with TB infection. In a TB endemic country like India, it is essential to understand the current burden of TB infection at the population level. The objective of the present analysis is to estimate the prevalence of TB infection in India and to explore the factors associated with TB infection. Methods: Individuals aged > 15 years in the recently completed National TB prevalence survey in India who were tested for TB infection by QuantiFERON-TB Gold Plus (QFT-Plus) assay were considered for this sub- analysis. TB infection was defined as positive by QFT-Plus (value > 0.35 IU/ml). The estimates for prevalence, prevalence ratio (PR) and adjusted risk ratio (aRR) estimates with 95% confidence intervals (CIs) were calculated. Results: Of the 16864 individuals analysed, the prevalence of TB infection was 22.6% (95% CI:19.4 −25.8). Factors more likely to be associated with TB infection include age > 30 years (aRR:1.49;95% CI:1.29–1.73), being male (aRR:1.26; 95%CI: 1.18–1.34), residing in urban location (aRR:1.58; 95%CI: 1.03–2.43) and past history of TB (aRR:1.49; 95%CI: 1.26–1.76). Conclusion: About one fourth (22.6%) of the individuals were infected with TB in India. Individuals aged > 30 years, males, residing in urban location, and those with past history of TB were more likely to have TB infection. Targeted interventions for prevention of TB and close monitoring are essential to reduce the burden of TB in India.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	Tuberculosis TB infection QFT-Plus IGRA Prevalence LTBI
Subjects:	Tuberculosis > Epidemiological Research
Divisions:	Epidemiology
Depositing User:	Mrs. N Lakshmi
Date Deposited:	17 Jan 2024 05:33
Last Modified:	17 Jan 2024 05:33
URI:	http://eprints.nirt.res.in/id/eprint/1981

Actions (login required)

View Item