Association of CYP27B1 gene polymorphisms with pulmonary tuberculosis and vitamin D levels

Harishankar, Murugesan and Sampath, Pavithra and Kumar, VA and Srividhya, R and Athikesavan, Veerasamy and Ranganathan, Uma Devi and Selvaraj, P and Bethunaickan, Ramalingam (2024) Association of CYP27B1 gene polymorphisms with pulmonary tuberculosis and vitamin D levels. Association of CYP27B1 gene polymorphisms with pulmonary tuberculosis and vitamin D levels, 927 (148679). pp. 1-7.

Text 202413.pdf - Published Version Download (571kB)

Abstract

Background and Objectives: Genetic factors are reported to be connected with tuberculosis (TB) infection. Studies have shown that genetic variations in genes involved in the vitamin D pathway influence the levels of vitamin D found in the bloodstream (serum). Cyp27b1 (1α-hydroxylase) is an enzyme that activates the synthesis of bioactive vitamin D3 by hydroxylation of 25(OH)D3. The in vitro studies reported rare gene variants of Cyp27b1 such as rs118204011 and rs118204012, associated with loss of Cyp27b1 function and lower serum vitamin D levels. Globally, a critical gap exists in understanding the link between these gene variants with TB and vitamin D levels. Hence, the study objective is to comprehend the association of Cyp27b1 rs118204009 (G/A), rs118204011 (C/T), and rs118204012 (A/G) with tuberculosis susceptibility/protection and to assess the influence of gene variants on vitamin D levels in both healthy controls (HCs) and those with pulmonary tuberculosis (PTB) in South India.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	Mycobacterium tuberculosis;Vitamin D;CYB27B1 gene polymorphism;Tuberculosis;Genetic susceptibility to TB
Subjects:	Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Immunology
Depositing User:	Mrs. N Lakshmi
Date Deposited:	26 Jul 2024 15:57
Last Modified:	26 Jul 2024 15:57
URI:	http://eprints.nirt.res.in/id/eprint/2007

Actions (login required)

View Item