High-dose isoniazid for TB with low-to-moderate isoniazid resistance after 1 week of treatment

Ranganathan, Uma Devi and Smith-Jeffcoat, SE and Balaji, S and Devika, K and Nair, Dina and Daniel, Bella Devaleenal and Srinivasan, R and Baskaran, M and Ravikumar, D and Sangamithirai, D and Radhika, Golla and Mangalambal, G and Lavanya, J and Maheswaran, K and Kumar, S and Sridhar, R. and Tripathy, S and Swaminathan, S and Eisenach, K D and Cegielski, J P (2025) High-dose isoniazid for TB with low-to-moderate isoniazid resistance after 1 week of treatment. High-dose isoniazid for TB with low-to-moderate isoniazid resistance after 1 week of treatment, 7(3).

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Abstract

To evaluate the effect of high-dose isoniazid in patients with isoniazid-resistant TB by its bactericidal activity after 1 or more weeks of treatment.Using the rapid direct method of phenotypic drug susceptibility testing, we screened persons with positive sputum microscopy results and genotypic drug resistance for isoniazid resistance.Those with no growth at a critical concentration of 2.0 mg/L were invited to participate in a trial of high-dose isoniazid monotherapy lasting 6 days. After 3 days of no treatment, patients received isoniazid 15 mg/kg and were followed with serial quantitative sputum cultures from Days 0 to 6

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/2051

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