Antituberculosis activity of α-aminoacyl amide derivatives

Makane, Vitthal B and Sinde, Akash U and Angayarkanni, B and Malik, Pradip and Chopra, Sidharth and Vijayan, N and Dusthackeer, Azger and Haridas, B (2025) Antituberculosis activity of α-aminoacyl amide derivatives. Antituberculosis activity of α-aminoacyl amide derivatives, 64 (114455).

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Abstract

The preparation and evaluation of α-aminoacyl amides derivatives against M. tuberculosis H37Rv is reported. The systematic modifications of hit compound were carried out. Compounds 19b and 19c are identified as potent and selective inhibitors of M. tuberculosis H37Rv with MIC 2.5 µM and 2.6 µM respectively. Compounds 19b and 19c hold a promise for further development to discover new potent antituberculosis lead.

Affiliation:	ICMR-National Institute for Research in Tubercuosis
Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/2113

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