Previous COVID-19 infection significantly reduces elastase levels in newly diagnosed pulmonary tuberculosis patients

Joseph, NH and Natarajan, AP and Natarajan, S and Ponnuraja, C and Madeshwaran, A and Gunaparvathy, I and Hemalatha, P and Rajeshwari, S and Jayabal, L and Ayyamperumal, M and Ramesh, P M and Hanna, L E (2025) Previous COVID-19 infection significantly reduces elastase levels in newly diagnosed pulmonary tuberculosis patients. Previous COVID-19 infection significantly reduces elastase levels in newly diagnosed pulmonary tuberculosis patients, 16 (158678).

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Abstract

Tuberculosis (TB) is considered a risk factor for severe COVID-19 disease and the quality of life of patients co-infected with COVID-19 and TB is significantly impacted due to the nature of these diseases. It is still unknown how our immune system will respond to both these pathogens in sequel. As it has been discovered that Neutrophil extracellular traps (NETs) result in caseating granulomas in TB and pathology in COVID-19, we conducted this work to determine the amounts of NET molecules in the bloodstream and to comprehend their function during TB and subsequent SARS-CoV-2 infection.

Affiliation:	ICMR- National Institute for Research in Tuberculosis
Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/2126

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