Human Pancreatic Islet Gene View in glucose homeostasis of Diabetic and Non-Diabetic Pancreases in the Indian population

Ponnuraja, C and Nithyakalyani, Mohan (2024) Human Pancreatic Islet Gene View in glucose homeostasis of Diabetic and Non-Diabetic Pancreases in the Indian population. Human Pancreatic Islet Gene View in glucose homeostasis of Diabetic and Non-Diabetic Pancreases in the Indian population, 8(1) (114-21).

Text 202439.pdf - Published Version Download (388kB)

Abstract

The pathogenesis of hyperglycemia observed in most forms of diabetes is intimately tied to the islet β cell. Impairments in pro-peptide processing and secretory function, along with the loss of these vital cells, are demonstrable not only in those in whom the diagnosis is established but typically also in individuals who are at increased risk of developing the disease. Due to ethical and practical difficulties, genomic or pathological data in Indian population are remarkably missing. Here we report genome transcript analysis validated by quantitative reverse transcription–polymerase chain reaction (qRT–PCR) for 21 pancreases. We analysed clinical-pathological features of 21 pancreases with the expression pattern of various genes which were involved in the glucosehomeostasis in order to understand their prognostic value. We also investigated the pathological differences between diabetic and non-diabetic samples and the expression of insulin in each case. This study provides an insight into the complex pattern of the gene expression disturbances that occur in the diabetic and non-diabetic pancreas

Affiliation:	ICMR- National Institute for Research in Tuberculosis
Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/2142

Actions (login required)

View Item