A double-blind controlled clinical trial to assess the role of anti-histamines in the treatment of multi-bacillary leprosy

Thomas, A and Nagarajan, M and Chandrasekaran, V and Hari, Lalitha and Somasundaram, P R and Prabhakar, R and Kumar, Ashok and Bhatia, V N and Roy, R G (1988) A double-blind controlled clinical trial to assess the role of anti-histamines in the treatment of multi-bacillary leprosy. Indian Journal of Leprosy, 60 (4). pp. 499-505. ISSN 0024-1024

Preview

PDF 198820.pdf - Published Version Download (23kB)

Abstract

A double blind controlled clinical trial to assess the role of antihistamines as a supplement in the treatment of leprosy was conducted in multibacillary cases of leprosy. In all, 120 patients with lepromatous or borderline leprosy were randomly allocated to a regimen of clofazimine and dapsone for 12 months with or without a supplement of pheniramine maleate for the first 3 months. During the 12-month period, 92% of the patients who received the supplement and 86% of the patients who had not received it had moderate or marked clinical improvement. The BI values decreased from 4.1 to 3.4 and 4.2 to 3.3, respectively. The results over the 12-month period showed that the addition of the antihistamine had not enhanced the efficacy of the regimen as evidenced by clinical and bacteriological findings.

Item Type:	Article
Subjects:	Tuberculosis > Clinical Research
Divisions:	Clinical Research
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	26 Aug 2013 05:34
Last Modified:	15 Mar 2016 05:59
URI:	http://eprints.nirt.res.in/id/eprint/246

Actions (login required)

View Item