Response of Patients Infected with Isoniazid-Resistant Tubercle Bacilli to Treatment with Isoniazid plus PAS Isoniazid Alone

Devadatta, S and Bhatia, A L and Andrews, R H and Fox, Wallace and Mitchison, D A and Radhakrishna, S and Ramakrishnan, C V and Selkon, J B and Velu, S (1961) Response of Patients Infected with Isoniazid-Resistant Tubercle Bacilli to Treatment with Isoniazid plus PAS Isoniazid Alone. Bulletin of the World Health Organization, 25 (6). pp. 807-829. ISSN 00429686

Preview

PDF RP196105.pdf - Published Version Download (190kB)

Abstract

This study from the Tuberculosis Chemotherapy Centre, Madras, compares patients infected with isoniazid-resistant tubercle bacilli (“R” patients) with those infected with isoniazid-sensitive tubercle bacilli (“S” patients) as regards, first, their pretreatment status and, secondly, their response to a year’s chemotherapy, either with isoniazid plus paminosalicylic acid (PAS) or with isoniazid alone. With regard to the first comparison, there was, on admission to treatment, little difference between the R and S patients in terms of the extent of the radiographic lesion, the extent of cavitation or the bacterial content of the sputum, but there were major differences in the age and sex distributions, the R patients showing a greater preponderance of young males than the S patients. As to the second comparison, statistically significant differences in the bacteriological response to treatment of the S and the R patients were observed in both the isoniazid-plus-PAS and the isoniazidalone series, the response of the S patients being much better than that of the R patients. When the response to treatment was assessed in terms of radiographic progress and weight changes, however, hardly any difference was observed between the progress of the S and the R patients. The reasons for the response in the R patients are discussed.

Item Type:	Article
Subjects:	Tuberculosis > Clinical Research
Divisions:	Clinical Research
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	15 Jul 2013 08:35
Last Modified:	08 Mar 2016 04:29
URI:	http://eprints.nirt.res.in/id/eprint/28

Actions (login required)

View Item