Early bactericidal action of pulsed exposure to rifampicin, ethambutol, isoniazid & pyrazinamide in pulmonary tuberculosis patients

Paramasivan, C N and Herbert, D and Umapthy, K C and Rahman, F and Krishnamurthy, P V and Prabhakar, R (1994) Early bactericidal action of pulsed exposure to rifampicin, ethambutol, isoniazid & pyrazinamide in pulmonary tuberculosis patients. Indian Journal of Medical Research, 100 (Jul). pp. 1-4. ISSN 0971-5916

Preview

PDF 199413.pdf - Published Version Download (25kB)

Abstract

The bactericidal action of two therapeutic regimens on Mycobacterium tuberculosis was assessed by viable counts in serial sputum samples in 49 pulmonary tuberculosis patients being treated with rifampicin (R), etbambutol (Emb), isoniazid (I) and pyrazinamide (Z) together in a single dose thrice weekly (REmbIZ3) or with REmb and IZ on alternate days (REmb3IZ3alt). In both groups of patients, there was a significant reduction (P < 0.02) in the colony forming units (cfu) of M. tuberculosis per ml of sputum during the first two days of treatment itself. This early bactericidal action (EBA) as well as the reduction in counts during the subsequent days of treatment were similar (P > 0.2) for both REmbIZ3 and REmb3IZ3alt regimens indicating that splitting up REmbIZ into REmb on one day and IZ on the next day in short course chemotherapy (SCC) regimens may not affect the bactericidal action of the regimens.

Item Type:	Article
Uncontrolled Keywords:	Early bactericidal activity, pulsed exposure, short course chemotherapy
Subjects:	Tuberculosis > Laboratory Research > Bacteriological
Divisions:	Basic Science Research > Bacteriology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	24 Sep 2013 08:20
Last Modified:	14 Mar 2016 05:59
URI:	http://eprints.nirt.res.in/id/eprint/378

Actions (login required)

View Item