IgG antibodies against antigens of various mycobactrial species in children and in pre & Post BCG young adults

Herbert, D and Paramasivan, C N and Datta, M and Vallishayee , R S and Prabhakar, R (1995) IgG antibodies against antigens of various mycobactrial species in children and in pre & Post BCG young adults. Indian Journal of Tuberculosis, 42 (1). pp. 15-21. ISSN 0019-5705

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Abstract

IgG antibodies against antigens of various mycobacteria were estimated by ELISA in serum samples collected (a) from 36 children (mean age 4.4 years) belonging to Koppur village in the south Indian BCG Trial area, (b) before and after BCG vaccination of 13 young individuals (mean age 16.5 years) belonging to Trivellore in the same area and (c) before and after BCG vaccination from 20 young British subjects (mean age 14.5 years). In the Koppur children, the antibody levels were highest against M. scrofulaceum and M. avium and lowest against M. bovis and M. tuberculosis H37Rv. In these children, there was no correlation between antibody levels and tuberculin reactivity. In the Trivellore subjects, antibody levels were highest against M. bovis BCG and M. gordonae, and lowest against PPD RT22 and M. terrae and none of the differences in the antibody levels against individual antigens between the preand post-BCG serum samples was statistically Significant (p >.05). The British subjects had the highest levels against M. tuberculosis 7219 while the lowest levels were against M. kansasii and M. tuberculosis 51; after BCG v a c c i n a t i o n t h e a n t i b o d y l e v e l s w e r e selectively increased against M. tuberculosis 7219, M. flavescens and M. gordornae (p <0.05).

Item Type: Article
Subjects: Tuberculosis > Laboratory Research > Bacteriological
Divisions: Basic Science Research > Bacteriology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 26 Sep 2013 07:18
Last Modified: 14 Mar 2016 05:24
URI: http://eprints.nirt.res.in/id/eprint/391

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