Interim findings on the evaluation of split drug regimens for pulmonary tuberculosis – A randomized controlled clinical trial

Tuberculosis Research Centre , Madras (1995) Interim findings on the evaluation of split drug regimens for pulmonary tuberculosis – A randomized controlled clinical trial. Indian Journal of Tuberculosis, 42 (4). pp. 201-206. ISSN 0019-5705

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Abstract

A randomized controlled clinical trial of three fully oral short course chemotherapy regimens of 6 month duration is being conducted to evaluate split-dose double drug combinations for the treatment of sputum positive pulmonary tuberculosis. Split I and Split II regimens consist of Rifa mpicin and Ethambutol on one day and lsoniazid and Pyrazinamide on the next day, each combination given thrice a week during the initial intensive phase of 2 or 3 months, respectively, followed by Rifampicin and Isoniazid given twice a week during the continuation phase for the next 4 and 3 months; respectively. The control regimen consists of all the four drugs, Rifampicin, Isoniazid, Pyrazinamide and Ethambutol, given together in a single dose thrice a week during the intensive phase of first 2 months, and Rifampicin and Isoniazid twice a week during the continuation phase of next 4 m o n t h s . D r u g s w e r e g i v e n u n d e r f u l l supervision during the entire chemotherapy period of 6 months. The findings upto the end of chemotherapy for 750 patients suggest that the response is similar in split and control regimens among patients with sensitive organisms and those with resistance to Isoniazid alone. Among patients with organisms resistant to both Isoniazid and Rifampicin, almost all had an unfavourable response. Adverse reactions were low and similar in both split and control regimens.

Item Type:	Article
Additional Information:	Study Paper
Subjects:	Tuberculosis > Clinical Research
Divisions:	Clinical Research
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	27 Sep 2013 06:46
Last Modified:	14 Mar 2016 05:34
URI:	http://eprints.nirt.res.in/id/eprint/411

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