In vitro susceptibility of clinical isolates of Mycobacterium tuberculosis to cefadroxil—a cephalosporin antibiotic

Selvakumar, N and Kumar, V and Paramasivan, C N (1997) In vitro susceptibility of clinical isolates of Mycobacterium tuberculosis to cefadroxil—a cephalosporin antibiotic. Indian Journal of Medical Research, 105 (Feb). pp. 58-60. ISSN 0971-5916

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Abstract

The bactericidal activity (BA) of cefadroxil, a semisynthetic cephalosporin antibiotic, against M. tuberculosis H37Rv was studied in Middlebrook 7H9 medium, Cefadroxil showed good BA (average fall of viable counts = log10 0.32 colony forming units/ml/day) against the log phase culture of M. tuberculosis H37Rv. Its minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) were found to be 15 μg/ml or less. The MIC of cefadroxil for 29 clinical isolates of M. tuberculosis and a laboratory strain, M. tuberculosis H37Rv was also determined by agar dilution method using Middlebrook 7H11 agar as a screening procedure. The MIC of cefadroxil was found to be 10 μg/ml or less for M. tuberculosis H37Rv and 16 (55.1%) of 29 clinical isolates tested. The MIC for 3 of 10 drug sensitive and 9 of 19 drug resistant isolates was 40 or more, a concentration much higher than the peak plasma concentration (28 μg/ml) attained in human beings. The higher MIC observed in 12 of 29 clinical isolates irrespective of their susceptibility pattern requires further studies to assess the usefulness of cefadroxil in the treatment of tuberculosis.

Item Type:	Article
Uncontrolled Keywords:	Cefadroxil, cephalosporin, M.tuberculosis, susceptibility
Subjects:	Tuberculosis > Laboratory Research > Bacteriological
Divisions:	Basic Science Research > Bacteriology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	29 Oct 2013 07:24
Last Modified:	14 Mar 2016 04:49
URI:	http://eprints.nirt.res.in/id/eprint/444

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