Evaluation of various methods of susceptibility to ofloxacin in strains of Mycobacterium tuberculosis

Sulochana, S and Venkataraman, P and Paramasivan, C N (1999) Evaluation of various methods of susceptibility to ofloxacin in strains of Mycobacterium tuberculosis. Indian Journal of Medical Research, 110 (Dec). pp. 186-189. ISSN 0971-5916

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Abstract

A comparison of three methods of susceptibility testing was undertaken on 30 susceptible and 25 resistant strains of Mycobacterium tuberculosis to determine an acceptable in vitro definition of resistance of ofloxacin. The strains were tested by the proportion method on Lowenstein Jensen (L-J) and 7H11 media and also by the BACTEC radiometric method. Using a criterion of 1 per cent or more growth at a concentration of 2 mg/1, there was a 100 per cent agreement with the conventional MIC method by the proportion tests on L-J as well as on 7H11 media. The BACTEC radiometric method, at the same concentration, yielded 98 per cent agreement. Thus, any of these methods could be used depending upon the infrastructure available.

Item Type:	Article
Uncontrolled Keywords:	Mycobacterium tuberculosis, Ofloxacin susceptibility test; tuberculosis
Subjects:	Tuberculosis > Laboratory Research > Bacteriological
Divisions:	Basic Science Research > Bacteriology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	04 Nov 2013 09:46
Last Modified:	10 Mar 2016 08:59
URI:	http://eprints.nirt.res.in/id/eprint/499

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