In Vitro Activity of Fluoroquinolones against Mycobacterium tuberculosis

Sulochana, S and Rahman, F and Paramasivan, C N (2005) In Vitro Activity of Fluoroquinolones against Mycobacterium tuberculosis. Journal of Chemotherapy, 17 (2). pp. 169-173. ISSN Print: 1120-009X; Online: 1973-9478

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Abstract

The in vitro activity of fluoroquinolones, including lomefloxacin, ofloxacin, ciprofloxacin. sparfloxacin, moxifloxacin and gatifloxacin, was evaluated against 55 clinical isolates of Mycobacterium tuberculosis by absolute concentration method on Lowenstein-Jensen (L-J) and Middlebrook's 7H11 media. Both ofloxacin susceptible and ofloxacin resistant strains of M. tuberculosis isolates were tested. The in vitro activities of these fluoroquinolones on the M. tuberculosis isolates were in the order: lomefloxacin<ciprofloxacin<ofloxacin<sparfloxacin<moxifloxacin=gati floxacin. Gatifloxacin and moxifloxacin showed low minimal inhibitory concentrations (MIC) for both ofloxacin resistant and ofloxacin susceptible strains even though some cross resistances were observed.

Item Type:	Article
Uncontrolled Keywords:	Mycobacterium tuberculosis, fluoroquinolones, lomefloxacin, ofloxacin, ciprofloxacin, sparfloxacin, moxifloxacin, gatifloxacin
Subjects:	Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Immunology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	29 Nov 2013 05:14
Last Modified:	09 Mar 2016 08:54
URI:	http://eprints.nirt.res.in/id/eprint/726

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