Promoter polymorphism of IL-18 gene in pulmonary tuberculosis in South Indian population

Harishankar, M and Selvaraj, P and Rajeswari, D N and Anand, S P and Narayanan, P R (2007) Promoter polymorphism of IL-18 gene in pulmonary tuberculosis in South Indian population. International Journal of Immunogenetics, 34 (5). pp. 317-320. ISSN Print: 1744-3121; Online: 1744-313X

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Abstract

Interleukin-18 (IL-18) plays a vital role in both innate and acquired immunity. We analysed polymorphisms at –607(C/A) and –137(G/A) in the promoter region of IL-18 gene by allele-specific polymerase chain reaction in normal healthy subjects (n = 173) and patients with pulmonary tuberculosis (n = 165). Allele, genotype and haplotype frequencies did not differ significantly between normal healthy subjects and patients. The results suggest that the IL-18 gene promoter polymorphisms are not associated with susceptibility or resistance to pulmonary tuberculosis in south Indian population of Dravidian descent.

Item Type:	Article
URI:	http://eprints.nirt.res.in/id/eprint/804

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