Short Communication: Association of HLA-A*1101 with Resistance and B*4006 with Susceptibility to HIV and HIV-TB: An in Silico Analysis of Promiscuous T Cell Epitopes

Raghavan, S and Selvaraj, P and Swaminathan, S and Narendran, G (2009) Short Communication: Association of HLA-A*1101 with Resistance and B*4006 with Susceptibility to HIV and HIV-TB: An in Silico Analysis of Promiscuous T Cell Epitopes. AIDS Research and Human Retroviruses, 25 (10). pp. 1023-1028. ISSN Print: 0889-2229; Online: 1931-8405

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Abstract

We have shown the association of HLA-A*11 with resistance and HLA-B*40 and -DR2 with susceptibility to HIV and HIV-TB. In the present study, we performed high-resolution subtyping of HLA-A*11 and -B*40 to identify the subtype level association, using the polymerase chain reaction-based sequence-specific oligonucleotide probe method. Underrepresentation of HLA-A*1101 was observed in overall HIV [pc¼0.012, OR 0.42 (95% confidence interval (CI) 0.24–0.72)] and HIVþTBþ [pc¼0.001, OR 0.18 (95% CI 0.06–0.46)] compared to healthy controls. Significantly higher frequencies of HLA-B*4006 were observed in overall HIV [p¼0.0001, pc¼0.004, OR 2.71 (95% CI 1.58–4.75)], HIVþTB– [p¼0.0003, pc¼0.008, OR 2.82 (95% CI 1.56–5.17)], and HIVþTBþ [p¼0.003, pc¼0.086, OR 2.56 (95% CI 1.33–4.95)] compared to healthy controls. An in silico analysis of potential T cell epitopes of consensus Gag and Pol sequences of HIV-1 subtype C Indian strains revealed relatively higher number of promiscuous HLA-B40, HLA-DRB1*1501, and -DRB1*1502 (HLA-DR2)-restricted epitopes in contrast to limited numbers of promiscuous binders restricted by HLA-A*1101. The results suggest that HLA-A*1101 may be associated with protection against HIV and the development of TB in HIV patients while HLA-B*4006 may be associated with susceptibility to HIV and TB development in HIV patients. The present study also suggests that the extent of promiscuity of T cell epitopes of HIV-1 subtype C restricted by HLA alleles exerting opposing effects might differ.

Item Type:	Article
Uncontrolled Keywords:	HLA-A; B*4006; HIV; tuberculosis; TB; Promiscuous T cell Epitopes;
Subjects:	Tuberculosis > Laboratory Research > Immunological HIV Tuberculosis
Divisions:	Basic Science Research > Immunology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	21 Nov 2017 09:16
Last Modified:	02 Mar 2021 06:28
URI:	http://eprints.nirt.res.in/id/eprint/975

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