Elevated Levels of Plasma Angiogenic Factors Are Associated with Human Lymphatic Filarial Infections

Bennuru, S and Maldarelli, G and Kumaraswami, V and Klion, A and Nutman, T B (2001) Elevated Levels of Plasma Angiogenic Factors Are Associated with Human Lymphatic Filarial Infections. American Journal of Tropical Medicine and Hygiene, 83 (4). pp. 884-890. ISSN Print: 0002-9637 | Electronic: 1476-1645

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Abstract

Lymphatic dilatation, dysfunction, and lymphangiogenesis are hallmarks of patent lymphatic filariasis, observed even in those with subclinical microfilaremia, through processes associated, in part, by vascular endothelial growth factors (VEGFs). A panel of pro-angiogenic factors was measured in the plasma of subjects from filaria-endemic regions using multiplexed immunological assays. Compared with endemic normal control subjects, those with both subclinical microfilaremia, and those with longstanding lymphedema had significantly elevated levels of VEGF-A, VEGF-C, VEGF-D, and angiopoeitins (Ang-1/Ang-2), with only levels of basic fibroblast growth factor (bFGF) and placental growth factor (PlGF) being elevated only if lymphedema was evident. Furthermore, levels of these factors 1-year posttreatment with doxycycline were similar to pretreatment levels suggesting a minimal role, if any, for Wolbachia . Our data support the concept that filarial infection per se is associated with elevated levels of most of the known pro-angiogenic factors, with only a few being associated with the serious pathologic consequences associated with Wuchereria bancrofti infection.

Affiliation:	ICMR-National Institute for Research in Tuberculosis
Item Type:	Article
Uncontrolled Keywords:	Plasma, Angiogenic, Lymphatic, Filarial Infections
Subjects:	Tuberculosis > Laboratory Research > Immunological
Divisions:	Basic Science Research > Immunology
Depositing User:	Dr. Rathinasabapati R
Date Deposited:	01 Jun 2022 07:39
Last Modified:	01 Jun 2022 09:16
URI:	http://eprints.nirt.res.in/id/eprint/1067

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