Outcome of standardized treatment for patients with MDR-TB from Tamil Nadu, India

Joseph, Pauline and Desai, Vijaya Baskara Rao and Mohan, Nalini Sunder and Fredrick, J S and Ramachandran, Rajeswari and Raman, Balambal and Wares, F and Ramachandran, Ranjani and Thomas, Aleyamma (2011) Outcome of standardized treatment for patients with MDR-TB from Tamil Nadu, India. Indian Journal of Medical Research, 133 (5). pp. 529-534. ISSN Print: 0971-5916 | Electronic: 0975-9174

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Background & objectives: Programmatic management of MDR-TB using a standardized treatment regimen (STR) is being implemented under the Revised National Tuberculosis Control Programme (RNTCP) in India. This study was undertaken to analyse the outcomes of MDR-TB patients treated at the Tuberculosis Research Centre, Chennai, with the RNTCP recommended 24 months STR, under programmatic conditions. Methods: Patients failed to the category II re-treatment regimen and confirmed to have MDR-TB, were treated with the RNTCP’s STR in a prospective field trial on a predominantly ambulatory basis. Thirty eight patients were enrolled to the trial from June 2006 to September 2007. Results: Time to culture conversion was two months or less for 82 per cent of patients. Culture conversion rates at 3 and 6 months were 84 and 87 per cent respectively. At the end of treatment, 25 (66%) were cured, 5 defaulted, 3 died and 5 failed. At 24 months, 30 (79%) patients, including 5 defaulters, remained culture negative for more than 18 months. Twenty two (58%) patients reported adverse drug reactions (ADRs) which required dose reduction or termination of the offending drug. No patient had XDR-TB initially, but 2 failure cases emerged as XDR-TB during treatment. Interpretation & conclusions: Outcomes of this small group of MDR-TB patients treated with the RNTCP’s STR is encouraging in this setting. Close attention needs to be paid to ensure adherence, and to the timely recognition and treatment of ADRs.

Affiliation: ICMR-National Institute for Research in Tuberculosis
Item Type: Article
Uncontrolled Keywords: Ambulatory treatment, India, multidrug-resistant TB, standardized regimen, MDR-TB, Tuberculosis, Tamil Nadu
Subjects: Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 16 Jun 2022 10:44
Last Modified: 07 Feb 2023 09:57
URI: http://eprints.nirt.res.in/id/eprint/1091

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