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Inactivators of Isoniazid, Based on The Ratio of The Urinary Excretion of Acetylisoniazid To Isoniazid

Venkataraman, P and Menon, N K and Nair, N G K and Radhakrishna, S and Ross, Chandra and Tripathy, S P (1972) Inactivators of Isoniazid, Based on The Ratio of The Urinary Excretion of Acetylisoniazid To Isoniazid. Indian Journal of Medical Research, 60 (5). pp. 685-693. ISSN 0971-5916

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Abstract

Following an intramuscular injection of isoniazid 3 mg/kg body-weight, the urinary excretion of isoniazid and acetylisoniazid during the periods 0-1, 1-2, 2-3 and 3-4 h was determined for 124 patients with pulmonary tuberculosis. On the same occasion, the serum isoniazid concentration at 4½ h was determined by microbiologic assay. The ratios of acetylisoniazid to isoniazid in the urine collections at 2, 3 and 4 h. were bimodally distributed. Rules were derived from these. ratios for classifying subjects as slow or rapid inactivators of isoniazid. There was 100% agreement between the classification based on each of these ratios and that based on the serum isoniazid concentration at 4½ h.

Item Type: Article
Subjects: Tuberculosis > Laboratory Research
Divisions: Basic Science Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 22 Jul 2013 06:01
Last Modified: 08 Mar 2016 10:33
URI: http://eprints.nirt.res.in/id/eprint/115

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