Selenium levels in persons with HIV/tuberculosis in India, Madurai City.

Ramakrishnan, Kuppamuthu and Shenbagarathai, R and Kavitha, K and Thirumalaikolundusubramanian, P and Rathinasabapati, R (2012) Selenium levels in persons with HIV/tuberculosis in India, Madurai City. Clinical laboratory, 58 (1-2). pp. 165-8. ISSN 1433-6510

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BACKGROUND Selenium plays a vital role in the immune status of the individual. The prospective observational study was conducted from September 2009 to March 2010. The aim of the present study is to investigate the association between serum selenium levels and pulmonary tuberculosis (PTB) patients with (n = 40) and without HIV (n = 40) in comparison to healthy controls (healthy family members; n = 20) who satisfied rigid selection criteria. METHODS Standard methods were adopted to collect an early morning fasting blood sample for serum selenium concentrations, determined by atomic absorption spectrometry (AAS), and albumin, determined by the bro mocresol green method. RESULTS The mean +/- SD for Body Mass Index (BMI), selenium, and albumin among the controls, HIV positive, and HIV negative patients were 19.6 +/- 0.6, 18 +/- 0.4 and 18.5 +/- 0.6 kg/m2; 113.1 +/- 4.1, 27.44 +/- 8, and 65.92 +/- 9, microg/dL; and 4.1 +/- 0.6, 2.9 +/- 0.4 and 3.6 +/- 0.7 g/dL, respectively. BMI, serum selenium, and albumin levels were found to be significantly lower (p < 0.004, p < 0.0321, and p < 0.002, respectively). CONCLUSIONS Low serum selenium levels are associated with increased risk of pulmonary infection caused by mycobacteria.

Affiliation: ICMR-National Institute for Research in Tuberculosis
Item Type: Article
Uncontrolled Keywords: Selenium Levels, HIV, Tuberculosis, India, Madurai
Subjects: Tuberculosis > Laboratory Research > Bacteriological
Tuberculosis > HIV - Basic Science
Divisions: Basic Science Research
Basic Science Research > Bacteriology
Information Science
Depositing User: Dr. Rathinasabapati R
Date Deposited: 15 Sep 2022 10:23
Last Modified: 15 Sep 2022 10:23

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