Effect of rifampicin & isoniazid on the steady state pharmacokinetics of moxifloxacin.

Ramachandran, Geetha and Hemanth Kumar, A K and Srinivasan, R and Geetharani, A and Sugirda, P and Nandhakumar, B and Nandini, R and Tharani, C B (2012) Effect of rifampicin & isoniazid on the steady state pharmacokinetics of moxifloxacin. The Indian journal of medical research, 136 (6). pp. 979-84. ISSN 0971-5916

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BACKGROUND & OBJECTIVES Moxifloxacin (MFX) is reported to have promising antimycobacterial activity, and has a potential to shorten tuberculosis (TB) treatment. We undertook this study to examine the influence of rifampicin (RMP) and isoniazid (INH) on the steady state pharmacokinetics of MFX individually in healthy individuals. METHODS A baseline pharmacokinetic study of MFX (400 mg once daily) was conducted in 36 healthy adults and repeated after one week of daily MFX with either RMP (450/600 mg) (n = 18) or INH (300 mg) (n = 18). Plasma MFX concentrations were determined by a validated HPLC method. RESULTS Plasma peak concentration and exposure of MFX was significantly lower and plasma clearance significantly higher when combined with RMP (P<0.001). The C max to MIC and AUC 0-12 to MIC ratios of MFX were significantly lower during concomitant RMP (P<0.001). INH had no significant effect on the pharmacokinetics of MFX. INTERPRETATION & CONCLUSIONS Concomitant RMP administration caused a significant decrease in C max and AUC 0-12 of MFX, the mean decreases being 26 and 29 per cent, respectively. It is uncertain whether this decrease would affect the treatment efficacy of MFX. Prospective studies in TB patients are needed to correlate MFX pharmacokinetics with treatment outcomes.

Affiliation: ICMR-National Institute for Research in Tuberculosis
Item Type: Article
Uncontrolled Keywords: Isoniazid - moxifloxacin - pharmacokinetics - rifampicin - tuberculosis
Subjects: Tuberculosis > Laboratory Research > Pharmacological
Divisions: Basic Science Research > Clinical Pharmacology
Depositing User: Dr. Rathinasabapati R
Date Deposited: 15 Sep 2022 10:59
Last Modified: 15 Sep 2022 11:09
URI: http://eprints.nirt.res.in/id/eprint/1206

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