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Classification of Subjects as Slow or Rapid Inactivators of Isoniazid Oral Administration of a Slow-release. Preparation of Isoniazid and Determination of the Ratio of Acetyisoniazid to Isoniazid in Urine

Kailasam, S and Immanuel, Chandra and Nair, N G K and Radhakrishna, S and Tripathy, S P (1975) Classification of Subjects as Slow or Rapid Inactivators of Isoniazid Oral Administration of a Slow-release. Preparation of Isoniazid and Determination of the Ratio of Acetyisoniazid to Isoniazid in Urine. Indian Journal of Medical Research, 63 (2). pp. 323-328. ISSN 0971-5916

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Abstract

A simple method for classifying subjects as slow or rapid inactivators of isoniazid has beenevaluated on large numbers of patients. The method consists of determining the ratio of acetylisoniazid to isoniazid in a 24-26 h. urine collection following the oral administration of a slow-release preparation of isoniazid 30 mg./kg. body-weight. In a group of 101 patients, there was 100 per cent agreement between the classification based on this method and that based on a standard method, consisting of estimation of the serum isoniazid concentration, 4½ h. after an intramuscular dose of ordinary isoniazid 3 mg./kg. body-weight. Subsequent studies in other patients have confirmed that the method is efficient, and demonstrated that the classification is highly reproducible.

Item Type: Article
Subjects: Tuberculosis > Laboratory Research
Divisions: Basic Science Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 23 Jul 2013 05:03
Last Modified: 09 Mar 2016 04:48
URI: http://eprints.nirt.res.in/id/eprint/121

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