Studies of immediate adverse reactions to different doses of a slow-release preparation of isoniazid

Parthasarathy, R and Devadatta, S and Fox, Wallace and Krishnaswami, K V and Radhakrishna, S and Somasundaram, P R and Tripathy, S P (1976) Studies of immediate adverse reactions to different doses of a slow-release preparation of isoniazid. Tubercle, 57 (2). pp. 115-121. ISSN 0041-3879

[thumbnail of 197601.pdf] PDF
197601.pdf - Published Version
Restricted to Registered users only

Download (63kB) | Request a copy

Abstract

‘Double-blind’ studies were carried out to assess the incidence of immediate adverse reactions to different doses of a slow-release preparation of isoniazid (matrix isoniazid). Individual doses of 30 mg/kg matrix isoniazid were well-tolerated but higher doses resulted in giddiness, the incidence being dose-related. The giddiness was characterized by a late onset and was usually present even at 24 hours. A few patients complained of gastro-intestinal symptoms. It is concluded that matrix isoniazid can be given to Madras patients in doses of 30-40 mg/kg without risk of an undue incidence of immediate adverse reactions.

Item Type: Article
Subjects: Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 23 Jul 2013 07:12
Last Modified: 10 Mar 2016 04:16
URI: http://eprints.nirt.res.in/id/eprint/123

Actions (login required)

View Item View Item