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Classification of Subjects as Slow or Rapid Inactivators of Isoniazid Based on the Ratio of Acetylisoniazid to Isoniazid in Urine Determined by a Simple Colorimetric Method

Raghupati Sarma, G and Kailasam, S and Kannapiran, M and Krishnaswami, K V and Thoma, Leila and Nair, N G K and Narayana, A S L (1976) Classification of Subjects as Slow or Rapid Inactivators of Isoniazid Based on the Ratio of Acetylisoniazid to Isoniazid in Urine Determined by a Simple Colorimetric Method. Indian Journal of Medical Research, 64 (10). pp. 1456-1461. ISSN 0971-5916

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Abstract

A method for classifying subjects as slow or rapid inactivators of isoniazid based on the ratio of acetylisoniazid to isoniazid in a 3-4 hour urine collection following an intramuscular dose of isoniazid 3 mg./kg. body-weight has been described. Isoniazid and acetylisoniazid have been estimated using methods requiring the use of only a photoelectric colorimeter. Of the 279 patients investigated, 169 (61 per cent) were classified as slow inactivators and 110 (39 per cent) as rapid inactivators. This classification is an excellent agreement (97 per cent) with that based on a standard spectrophotometric method.

Item Type: Article
Subjects: Tuberculosis > Laboratory Research
Divisions: Basic Science Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 23 Jul 2013 09:35
Last Modified: 10 Mar 2016 04:16
URI: http://eprints.nirt.res.in/id/eprint/126

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