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Comparison of various measures of sensitivity of M. tuberculosis to ethambutol.

Subbammal, S and Nair, N G K and Radhakrishna, S and Tripathy, S P (1978) Comparison of various measures of sensitivity of M. tuberculosis to ethambutol. Tubercle, 59 (3). pp. 185-191. ISSN 0041-3879

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Abstract

A sensitivity test for ethambutol was standardised, and performed on cultures isolated from patients before and after the start of chemotherapy with ethambutol and isoniazid. A discrimination type of approach was employed and three criteria of resistance were evolved : (a) growth of 20 colonies or more on ethambutol 4 μg/ml, using a standard inoculum ; (b) a proportion of 25 % or more on ethambutol 1.4 μg/ml ; (c) a proportion of 5 % or more on ethambutol 2 μg/ml. The MIC definition appears to be the best in view of its simplicity and insensitivity of the classification (as sensitive or resistant) to variations in inoculum size.

Item Type: Article
Subjects: Tuberculosis > Laboratory Research
Divisions: Basic Science Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 25 Jul 2013 09:20
Last Modified: 10 Mar 2016 05:09
URI: http://eprints.nirt.res.in/id/eprint/134

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