Effectiveness of symptom screening and incidence of tuberculosis among adults and children living with HIV infection in India.

Padmapriyadarsini, C and Bhavani, P K and Sekar, L and Selvaraj, M and Poornagangadevi, N and Mothi, S N and Nandagopal, K and Vennila, S and Priyadarshini, G K and Manisha, Mahesh and Sanjeeva, G and Agarwal, Upasna and Suresh, E and Rewari, B B and Swaminathan, Soumya Effectiveness of symptom screening and incidence of tuberculosis among adults and children living with HIV infection in India. The National medical journal of India, 29 (6). pp. 321-325. ISSN 0970-258X

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BACKGROUND WHO recommends the use of a simplified symptom-based algorithm for screening for tuberculosis (TB) among people living with HIV (PLHIV). We assessed the feasibility and effectiveness of this algorithm and determined the prevalence and incidence of TB among PLHIV attending antiretroviral treatment (ART) centres in India. METHODS We did a prospective multicentric implementation research study in four states of India. To rule out TB, we administered the WHO symptom-screen algorithm to all PLHIV every month for 6 months. If they were found to be symptomatic any time during this period, they were referred for investigations for TB. A case of TB diagnosed during the first month of screening was taken as a prevalent case while those detected TB in the subsequent 5 months were considered cases of incident TB. We calculated the incidence rate using the person-years method. Results . Between May 2012 and October 2013, a total of 6099 adults and 1662 children living with HIV were screened for TB at the ART centres of four states. Of the 6099 adult PLHIV, 1815 (30%) had at least one symptom suggestive of TB, of whom only 634 (35%) were referred for investigations of TB. Of those referred, 97 (15%) PLHIV were diagnosed with TB. Overall, the prevalence of undiagnosed TB was 0.84 person-years and in the subsequent period, the incidence of TB was 2.4/100 person-years (95% CI 1.90-3.10). Among 1662 children, 434 (26%) had at least one symptom suggestive of TB. But only 57 (13%) children were referred for investigations of TB and 13 (23%) of them were diagnosed with TB. The prevalence of TB among children was 0.5% and its incidence among them was 2.7/100 person-years (95% CI 1.60-4.30). CONCLUSION Prevalence and incidence of TB is high among PLHIV attending ART centres. This emphasizes the need to strengthen regular screening for symptoms of TB and further referral of those symptomatic for diagnosis of TB.

Affiliation: ICMR-National Institute for Research in Tuberuclosis
Item Type: Article
Uncontrolled Keywords: tuberculosis, adults, children, HIV infection, India
Subjects: Tuberculosis > Clinical Research
Divisions: Clinical Research
Depositing User: Dr. Rathinasabapati R
Date Deposited: 14 Oct 2022 09:58
Last Modified: 14 Oct 2022 09:58
URI: http://eprints.nirt.res.in/id/eprint/1491

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